Ability of Circulating Human Hematopoietic Lineage Negative Cells to Support Hematopoiesis
نویسندگان
چکیده
منابع مشابه
HEMATOPOIESIS AND STEM CELLS RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are pluripotent stem cells (PSCs), which can differentiate into nearly all types of cells and have self-renewal ability. Recent advancements in hESC and iPSC production have revolutionized their potential applications in regenerative medicine. Many patients with blood disorders can be treated or even cured with hemato...
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1Department of Transfusion Medicine, Laboratory of Stem Cells, Spirito Santo Hospital, Pescara, Italy; 2Laboratory of Clinical and Experimental Immunology, Department of Translational Medicine, University of Milan and IRCCS Istituto Clinico Humanitas, Rozzano, Milano, Italy; 3Center for Cancer Research, National Cancer Institute, Laboratory of Cellular Oncology, National Institutes of Health (N...
متن کاملHematopoietic stem cells and hematopoiesis.
BACKGROUND The highly orchestrated process of blood cell development and homeostasis is termed "hematopoiesis." Understanding the biology of hematopoietic stem cells as well as hematopoiesis is important to developing improved treatments for hematologic malignancies, congenital disorders, chemotherapy-related cytopenias, and blood and marrow transplants. METHODS The author reviews the current...
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Age-associated changes of T and NK cell (T/NK) potential of human hematopoietic stem cells are unknown. In this study, we enumerate and characterize T/NK precursors among CD34(+)Lin(-) cell populations circulating in normal human adult peripheral blood (PB) by a limiting-dilution assay using coculture with OP9-DL1 stroma cells expressing Notch 1 ligand, Delta-like 1. The frequency of T cell pre...
متن کاملLead acetate reduces the ability of human umbilical cord mesenchymal stem cells to support hematopoiesis in vitro.
Plumbum (Pb) is a heavy metal toxin that causes many pathophysiological effects in various systems of the human body. It has previously been reported that excessive lead trioxide causes hematopoietic system toxicity. Mesenchymal stem cells (MSCs), as cells with self-renewal and multipotent differentiation potential, play a supportive role in hematopoietic function. Lead is well known to interfe...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2014
ISSN: 0730-2312
DOI: 10.1002/jcb.24942